Drug title

Imuran (Azathioprine)

Usage indications

Imuran is used for the treatment of rheumatoid arthritis heavy cases. It decreases undesirable immune reaction and helps to prevent rejection of the transplants.

Application mode

Use Imuran in accordance with your doctor indications.

• Take Imuran during or after meal. Take it together with food to decrease stomach upset in case if any.
• consult with your doctor on this drug intake.

Mechanism of action

Imuran is an antimetabolite. It acts by decreasing the influence of specific cells at organism immune system.

Missed doses

Take Imuran  as soon as you remember about it. If it happened during next dosage intake time take missed dose and then follow intake schedule. The intake of two pills in one day is prohibited.

Storage

Store Imuran at room temperature of 68- 77 F degrees (20 - 25 С degrees). Keep away from the sources of heat,  humidity and light, children and pets.

Precautions

Do not use Imuranif:

• you are allergic to any of its component;
• you have tumor or unusual growth;
• you have rheumatoid arthritis or pregancy;
• you take mercaptoturin.

Contact your doctor at once if any of the following relates to you.

Important:

• Imuran can decrease your ability to fight infections. Avoid contacting people with flu. Inform your doctor on any signs of infections such as fever, sore throat, rash or shivering.
• Imuran can decrease the amount of trombocites in blood. Avoid the activity which might cause unusual bruises or bleedings. Inform your doctor if you have dark, resinous or bloody stool.
• inform your doctor or dentist about Imuran intake before getting any medical or dental help, urgent medical help or surgery.
• inform your doctor about Imuran intake before making any injections.
• contact your doctor at once if you have strong  vomiting or nausea. It might be accompanied by diarrhea, rash, fever, muscle pains or giddiness. Such reaction occurs usually within first several weeks of treament.
• Imuran can increase the risk of edema development or the development of other cancer diseases. Contact your doctor  once you noticed any outgrowths or clots.
• TPMT ferment helps to destroy Imurtan the organism contains.  In rare cases some patients might have TPMT decreased activity. This can increase the risk of serious side effects development (serious marrow problems). The patients with TPMT ferment decreased activity might require Imuran dose.
• Laboratory tests such as blood analysis, liver function, TPMT  ferment activity analysis can be performed during Imuran intake. These tests can be used for your condition assessment  for side effect revealing.
• children should be cautious when using Imuran as its safety and efficiency had not been confirmed.
• pregnancy and breast feeding: Imuran can possibly harm foeutus. Do not take Imuran if you are pregnant. Contact your doctor if you suspect of being pregnant. You will need to discuss the advantages and risks of Imuran usage during pregnancy. Imuran is present at mother milk. Do not do breast feeding during this drug intake.

Side effects

Consult with your doctor if any of the most widespread effects persist or irritate:

• light vomiting or nausea.

Contact your doctor immediately if any of the following serious side effects arise:

• heavy allergic reactions (rash, nettle rash, itch, breathing difficulties, chest constraint, mouth, lips, face or tongue edema), chest pain or constraints, dark urine, increased  temperature, shivering or sore throat, painful urination, muscle pain; pale or greasy stool, heavy or constant vomiting, nausea or diarrhea, short breath, stomach pains, unusual bleeding or bruises, unusual outgrowths, unusual weakness or tiredness, eyes or skin yellowing.

Additional information

Imuran should be used on doctor’s prescription only.
Consult with your doctor in case of symptoms’ non- improvement  or getting worse.